Involvement of brown adipose tissue in subcutaneous fat necrosis of the newborn

• Published in: Dermatology (Basel) Vol. 223; no. 3; p. 207
• Main Authors: Ichimiya, H, Arakawa, S, Sato, T, Shimada, T, Chiba, M, Soma, Y, Mizoguchi, M, Tomonari, K, Iwasaka, H, Hatano, Y, Okamoto, O, Fujiwara, S
• Format: Journal Article
• Language: English
• Published: Switzerland 01-01-2011
• Subjects: Adipose Tissue, Brown - diagnostic imaging; Adipose Tissue, Brown - pathology; Adipose Tissue, Brown - ultrastructure; Biopsy; Child; Child, Preschool; Fat Necrosis - diagnostic imaging; Fat Necrosis - pathology; Female; Fluorodeoxyglucose F18; Humans; Infant, Newborn; Ion Channels - immunology; Ion Channels - ultrastructure; Male; Mitochondrial Proteins - immunology; Mitochondrial Proteins - ultrastructure; Multimodal Imaging; Positron-Emission Tomography; Subcutaneous Fat - diagnostic imaging; Subcutaneous Fat - pathology; Subcutaneous Fat - ultrastructure; Tomography, X-Ray Computed; Uncoupling Protein 1
• ISSN: 1421-9832
• DOI: 10.1159/000331810

Subcutaneous fat necrosis (SCFN) of the newborn is a rare condition that manifests within days after birth. The interscapular region, axillae and shoulders are the most commonly affected sites, corresponding to anatomic sites of brown adipose tissue (BAT) in newborns.
We postulated a specific involvement of BAT in SCFN and searched for brown adipocytes at affected sites.
Biopsy specimens were immunostained with antibodies against uncoupling protein 1 (UCP-1) and examined by electron microscopy. We also examined BAT by (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography and computed tomography (PET-CT) scanning.
A few cells in biopsy specimens from two patients bound antibodies against UCP-1, and brown adipocytes were detected at several stages of degeneration. PET-CT scans revealed lower uptake of (18)F-FDG at major sites of SCFN.
SCFN and BAT can be found at the same sites, suggesting a pathophysiological connection.