Lipopeptides in microbial infection control: Scope and reality for industry

• Published in: Biotechnology advances Vol. 31; no. 2; pp. 338 - 345
• Main Authors: Mandal, Santi M., Barbosa, Aulus E.A.D., Franco, Octavio L.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Inc 01-03-2013; Elsevier
• Subjects: anidulafungin; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antimicrobials; Bacterial infections; Biological and medical sciences; biosurfactants; Biotechnology; caspofungin; Cosmetics - pharmacology; cytotoxicity; daptomycin; disease control; Drug Industry; emulsifiers; Emulsifying Agents - pharmacology; Food Industry; food production; foods; Fundamental and applied biological sciences. Psychology; Lipopeptides; Lipopeptides - pharmacology; micafungin; Molecular Structure; pharmaceutical industry; product development; Structure-Activity Relationship; Biotechnology; Bacterial infections; Antimicrobials; Lipopeptides; Industry; Infection; Bacteriosis; Microorganism; Antimicrobial agent; Lipopeptide
• ISSN: 0734-9750; 1873-1899
• DOI: 10.1016/j.biotechadv.2013.01.004

Lipopeptides are compounds that are formed by cyclic or short linear peptides linked with a lipid tail or other lipophilic molecules. Recently, several lipopeptides were characterized, showing surfactant, antimicrobial and cytotoxic activities. The properties of lipopeptides may lead to applications in diverse industrial fields including the pharmaceutical industry as conventional antibiotics; the cosmetic industry for dermatological product development due to surfactant and anti-wrinkle properties; in food production acting as emulsifiers in various foodstuffs; and also in the field of biotechnology as biosurfactants. Some lipopeptides have reached a commercial antibiotic status, such as daptomycin, caspofungin, micafungin, and anidulafungin. This will be the focus of this review. Moreover, the review presented here will focus on the biotechnological utilization of lipopeptides in different fields as well as the functional–structure relation, connecting recent aspects of synthesis and structure diversity.
► The lipopeptide properties are related to diverse industrial applications. ► Numerous lipopeptides patents are here described. ► The lipopeptides functional–structure relation is focused.