Role of vacuolar-type proton ATPase in signal transduction

• Published in: Biochimica et biophysica acta. Bioenergetics Vol. 1847; no. 10; pp. 1166 - 1172
• Main Authors: Sun-Wada, Ge-Hong, Wada, Yoh
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-10-2015
• Subjects: mTOR; Notch; Signaling pathway; V-ATPase; Wnt; mTOR; V-ATPase; Signaling pathway; Wnt; Notch
• ISSN: 0005-2728; 1879-2650
• DOI: 10.1016/j.bbabio.2015.06.010

The vacuolar H+-ATPase (V-ATPase) was first identified as an electrogenic proton pump that acidifies the lumen of intra- and extracellular compartments. The acidic pH generated by V-ATPase is important for a wide range of cellular processes as well as acidification-independent processes such as secretion and membrane fusion. In addition to these housekeeping functions, recent studies implicate V-ATPase in the direct regulation and function of signaling pathways. In this review, we describe recent findings on the functions of V-ATPase in growth regulation and tissue physiology.
•V-ATPase-regulated endocytic trafficking is essential for signal transduction.•V-ATPase functions as an intrinsic part of various signaling mechanisms.•Catalytic activity of V-ATPase provides feedback control for intracellular signaling.