Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review

• Published in: European journal of medicinal chemistry Vol. 97; pp. 419 - 443
• Main Authors: Yadav, Geeta, Ganguly, Swastika
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 05-06-2015
• Subjects: Animals; Anthelmintics; Benzimidazole; Benzimidazoles - chemistry; Benzimidazoles - pharmacology; Drug Discovery; Heterocyclic ring systems; Humans; Molecular Structure; Pharmacological activities; SAR study; Structure-Activity Relationship; VV; NO; SAR; Anthelmintics; INHR-MTB; PDE; CYP450; BuChE; Benzimidazole; Heterocyclic ring systems; NPY; GKAs; HBV; AChE; DPPH; MIC; YFV; DGAT; Pharmacological activities; SAR study; CVB; RSV; BVDV; HCV; MTB; PK; ABTS
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2014.11.053

Benzimidazoles are the fused heterocyclic ring systems which form an integral part of vitamin B12 and have been luring many researchers all over the world to assess their potential therapeutic significance. They are known for their crucial role in numerous diseases via various mechanisms. Substitution of benzimidazole nucleus is a crucial step in the drug discovery process. Therefore, it is necessary to gather the latest information along with the earlier information to understand the present status of benzimidazole nucleus in drug discovery. In the present review, benzimidazole derivatives with different pharmacological activities are described on the basis of SAR study using structural substitution pattern around the benzimidazole nucleus and aims to review the reported work related to the chemistry and pharmacological activities of benzimidazole derivatives during recent years. The present manuscript to the best of our knowledge is the first compilation on synthesis and medicinal aspects including structure–activity relationships of benzimidazole reported to date.
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•Diverse biological activities of benzimidazole have been discussed.•Synthesis and Chemistry of benzimidazole scaffold has been discussed.•Covered recent literature on benzimidazole scaffold.•Main focus is on Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities.