EASI p-EASI: Utilizing a combination of serum biomarkers offers an objective measurement tool for disease severity in atopic dermatitis patients

• Published in: Journal of allergy and clinical immunology Vol. 140; no. 6; pp. 1703 - 1705
• Main Authors: Thijs, Judith L., Drylewicz, Julia, Fiechter, Renée, Strickland, Ian, Sleeman, Matthew A., Herath, Athula, May, Richard D., Bruijnzeel-Koomen, Catharina A.F.M., Knol, Edward F., Giovannone, Barbara, de Bruin-Weller, Marjolein S., Nierkens, Stefan, Hijnen, Dirk Jan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-12-2017; Elsevier Limited
• Subjects: Antigen-presenting cells; Atopic dermatitis; Biomarkers; Biomarkers - blood; Chemokine CCL17 - blood; Chemokines; Cytokines; Dermatitis; Dermatitis, Atopic - blood; Helper cells; Humans; Interleukin-22; Interleukins - blood; Lymphocytes; Pathogenesis; Psoriasis; Receptors, Interleukin-2 - blood; Severity of Illness Index; Studies; Systematic review
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2017.06.046

Combining levels of biomarkers in an algorithm provides a single, easy-to-interpret value. Because the algorithm was developed to predict EASI scores, we named this outcome measure the predicted-EASI (p-EASI). [...]we have invented a biomarker signature (p-EASI) consisting of TARC, IL-22, and sIL-2R that provides a reliable and objective measure of disease severity in patients with AD. Supplementary data 1 J. Thijs, T. Krastev, S. Weidinger, C.F. Buckens, M. de Bruin-Weller, C. Bruijnzeel-Koomen, Biomarkers for atopic dermatitis: a systematic review and meta-analysis, Curr Opin Allergy Clin Immunol, Vol. 15, 2015, 453-460 2 J. Landheer, M. de Bruin-Weller, C. Boonacker, D. Hijnen, C. Bruijnzeel-Koomen, H. Rockmann, Utility of serum thymus and activation-regulated chemokine as a biomarker for monitoring of atopic dermatitis severity, J Am Acad Dermatol, Vol. 71, 2014, 1160-1166 3 J.L. Thijs, S. Nierkens, A. Herath, C.A. Bruijnzeel-Koomen, E.F. Knol, B. Giovannone, A panel of biomarkers for disease severity in atopic dermatitis, Clin Exp Allergy, Vol. 45, 2015, 698-701 4 T. Imai, M. Nagira, S. Takagi, M. Kakizaki, M. Nishimura, J. Wang, Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine, Int Immunol, Vol. 11, 1999, 81-88 5 G.N. Gaulton, P. Williamson, Interleukin-2 and the interleukin-2 receptor complex, Chem Immunol, Vol. 59, 1994, 91-114 6 C. Walker, M.K. Kagi, P. Ingold, P. Braun, K. Blaser, C.A. Bruijnzeel-Koomen, Atopic dermatitis: correlation of peripheral blood T cell activation, eosinophilia and serum factors with clinical severity, Clin Exp Allergy, Vol. 23, 1993, 145-153 7 D. Gutowska-Owsiak, A.L. Schaupp, M. Salimi, S. Taylor, G.S. Ogg, Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes, Br J Dermatol, Vol. 165, 2011, 492-498 8 K.E. Nograles, L.C. Zaba, A. Shemer, J. Fuentes-Duculan, I. Cardinale, T. Kikuchi, IL-22-producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells, J Allergy Clin Immunol, Vol. 123, 2009, 1244-1252.e2 9 D. Hijnen, E.F. Knol, Y.Y. Gent, B. Giovannone, S.J. Beijn, T.S. Kupper, J Invest Dermatol, Vol. 133, 2013, 973-979