A comparison of the inhibitory effect of cromoline and nedocromil Na on histamine release from airway metachromatic cells and from peripheral basophils

• Published in: Immunology letters Vol. 53; no. 2; pp. 147 - 151
• Main Authors: Kivity, S., On, A., Agami, O., Levo, Y., Fireman, E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-11-1996
• Subjects: Adult; Airway metachromatic cells; Anti-Asthmatic Agents - pharmacology; Antibodies, Anti-Idiotypic - pharmacology; Asthma - blood; Asthma - immunology; Basophils - drug effects; Bronchi - cytology; Bronchial asthma; Concanavalin A - pharmacology; Cromolyn Sodium - pharmacology; Female; Forced Expiratory Volume; Histamine release; Histamine Release - drug effects; Humans; Immunoglobulin E - immunology; Interleukin-3 - pharmacology; Male; Nedocromil - pharmacology; Peripheral basophils; Sputum - cytology; Bronchial asthma; Peripheral basophils; Airway metachromatic cells; Histamine release
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/S0165-2478(96)02627-2

Metachromatic cells are increased in the airways of asthmatic patients. We obtained metachromatic cells from asthmatic airways using an induced sputum technique. The histamine release following ConA, anti-IgE and anti-IgE + IL
3 from those cells were evaluated before and following the addition of cromoline Na and nedocromil Na. Metachromatic cells had a higher rate of spontaneous histamine release when compared to peripheral basophils. Cromoline Na and nedocromil Na inhibited histamine release from triggered metachromatic cells but not from peripheral basophils. It is concluded that airway metachromatic cells from asthmatics behave differently than peripheral basophils.