Oxidative stress parameters in dogs naturally infected with sarcoptic mange

• Published in: Revista Colombiana de Ciencias Pecuarias Vol. 36; no. 4; pp. 172 - 180
• Main Authors: Yanar, Kerim Emre, Kucukler, Sefa, Eren, Emre, Eroglu, Muhammed Sertaç, Ilgun, Murat, Gur, Cihan, Kandemir, Fatih Mehmet, Aktas, Mustafa Sinan
• Format: Journal Article
• Language: English
• Published: Medellín Universidad de Antioquía 01-10-2023; Universidad de Antioquia
• Subjects: Alopecia; Animals; Antioxidants; Baldness; biomarcador; biomarker; Blistering; cachorro; dog; Dogs; Elbow; escabiosis; estresse oxidativo; estrés oxidativo; Glutathione; Hematology; infestación; infestation; infestação; Itching; Nitric oxide; Oxidants; oxidative stres; Oxidative stress; Oxidizing agents; perro; Sarcoptes; Sarcoptes scabiei; sarcoptic mange; sarna; sarna sarcóptica; Scabies; Skin diseases; zoonose; Zoonoses; zoonosis
• ISSN: 0120-0690; 2256-2958
• DOI: 10.17533/udea.rccp.v36n4a2

Background: Scabies is one of the most common diseases in dogs. It threatens both animals and humans due to its zoonotic potential. Objective: The purpose of this study was to evaluate the oxidant/antioxidant balance with hematological findings in dogs infested with sarcoptic mange. Methods: The animals evaluated in this study consisted of 32 mixedbreed dogs between 1 and 2 years of age. The dogs were allocated into two groups: a control group (infestationfree animals; n=10), and a sarcoptic mangeinfected group (Sarcoptes, n=22). Dogs in the Sarcoptes group showed infestation signs such as intense itching, excoriations, alopecia, and blistering of the elbow and auricular margins. Results: Significant increase (p<0.01) levels were observed in total oxidant status (TOS), malondialdehyde (MDA), oxidative stress index (OSI), and nitric oxide (NO), while glutathione (GSH) and total antioxidant status (TAS) levels in dogs infested with Sarcoptes decreased significantly (p<0.01). In addition, a significant increase (p<0.01) of WBC count in dogs in the sarcoptic group in comparison with the control was found. Conversely, there was significant decrease (p<0.01) in RBC, HGB, and PCV counts in Sarcoptesinfested dogs. Conclusions: Our study suggests a possible relationship between oxidant/antioxidant imbalance and hematological findings in dogs infested with sarcoptic mange. Furthermore, in addition to MDA, TAS, TOS, and OSI markers, NO as well as GSH might be also used to assess the oxidative stress in dogs naturally infected with Sarcoptes scabiei.