A variation in the infant oxytocin receptor gene modulates infant hippocampal volumes in association with sex and prenatal maternal anxiety

• Published in: Psychiatry research. Neuroimaging Vol. 307; p. 111207
• Main Authors: Acosta, H., Tuulari, J.J., Kantojärvi, K., Lewis, J.D., Hashempour, N., Scheinin, N.M., Lehtola, S.J., Fonov, V.S., Collins, D.L., Evans, A., Parkkola, R., Lähdesmäki, T., Saunavaara, J., Merisaari, H., Karlsson, L., Paunio, T., Karlsson, H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30-01-2021
• Subjects: Adult; Amygdala; Anxiety - diagnostic imaging; Anxiety - genetics; Brain development; Caudate; Female; GxE interaction; Hippocampus; Hippocampus - diagnostic imaging; Humans; Infant; Magnetic Resonance Imaging; Male; MRI; Oxytocin; Pregnancy; Receptors, Oxytocin - genetics; Rs53576; Caudate; Amygdala; MRI; GxE interaction; Brain development; Rs53576; Hippocampus
• ISSN: 0925-4927; 1872-7506
• DOI: 10.1016/j.pscychresns.2020.111207

•Sex-specific association of oxytocin receptor genotype with infant brain volumes:.•Larger left hippocampal volumes in male, but not female GG-homozygotes of rs53576.•Interaction of rs53576 and prenatal maternal anxiety on right hippocampal volumes:.•Higher maternal anxiety linked to larger hippocampal volumes in A-allele carriers.
Genetic variants in the oxytocin receptor (OTR) have been linked to distinct social phenotypes, psychiatric disorders and brain volume alterations in adults. However, to date, it is unknown how OTR genotype shapes prenatal brain development and whether it interacts with maternal prenatal environmental risk factors on infant brain volumes.
In 105 Finnish mother-infant dyads (44 female, 11–54 days old), the association of offspring OTR genotype rs53576 and its interaction with prenatal maternal anxiety (revised Symptom Checklist 90, gestational weeks 14, 24, 34) on infant bilateral amygdalar, hippocampal and caudate volumes were probed.
A sex-specific main effect of rs53576 on infant left hippocampal volumes was observed. In boys compared to girls, left hippocampal volumes were significantly larger in GG-homozygotes compared to A-allele carriers. Furthermore, genotype rs53576 and prenatal maternal anxiety significantly interacted on right hippocampal volumes irrespective of sex. Higher maternal anxiety was associated both with larger hippocampal volumes in A-allele carriers than GG-homozygotes, and, though statistically weak, also with smaller right caudate volumes in GG-homozygotes than A-allele carriers.
Our study results suggest that OTR genotype enhances hippocampal neurogenesis in male GG-homozygotes. Further, prenatal maternal anxiety might induce brain alterations that render GG-homozygotes compared to A-allele carriers more vulnerable to depression.