Recent development in transition metal-catalysed C-H olefination

• Published in: Chemical science (Cambridge) Vol. 12; no. 8; pp. 2735 - 2759
• Main Authors: Ali, Wajid, Prakash, Gaurav, Maiti, Debabrata
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 29-01-2021; The Royal Society of Chemistry
• Subjects: Chemical synthesis; Chemistry; Covalent bonds; Hydrogen bonds; Organic chemistry; Regioselectivity; Transition metals
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/d0sc05555g

Transition metal-catalysed functionalizations of inert C-H bonds to construct C-C bonds represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of directing groups, catalysts and ligands has played a crucial role in selective C-H bond (sp
2
or sp
3
) activation. Recent developments in these areas have assured a high level of regioselectivity in C-H olefination reactions. In this review, we have summarized the recent progress in the oxidative olefination of sp
2
and sp
3
C-H bonds with special emphasis on distal, atroposelective, non-directed sp
2
and directed sp
3
C-H olefination. The scope, limitation, and mechanism of various transition metal-catalysed olefination reactions have been described briefly.
Transition metal-catalysed functionalizations of inert C-H bonds to construct C-C bonds represent an ideal route in the synthesis of valuable organic molecules.