Unmet therapeutic goals and potential treatable traits in a population of patients with severe uncontrolled asthma in Spain. ENEAS study

• Published in: Respiratory medicine Vol. 151; pp. 49 - 54
• Main Authors: Pérez de Llano, Luis, Martínez-Moragón, Eva, Plaza Moral, Vicente, Trisan Alonso, Andrea, Sánchez, Carlos Almonacid, Callejas, Francisco Javier, Vera, Elisabeth, Soto Campos, Jose Gregorio, Martinez Rivera, Carlos, Alcázar Navarrete, Bernardino, Urrutia Landa, Isabel, Garcia Rivero, Juan Luis, Padilla Galo, Alicia, Alvarez Gutierrez, Francisco, Landete, Pedro, Ramos González, Jacinto, Aracil, Cleofé Fernández, Carretero Gracia, José Ángel, Lluch, Inmaculada, Puente, Luis, Andujar-Espinosa, Ruben, Cosío, Borja Garcia
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-05-2019; Elsevier Limited
• Subjects: Airway management; Airway Obstruction - epidemiology; Asthma; Asthma - drug therapy; Asthma - epidemiology; Biological products; Biomarkers; Biomarkers - blood; Body mass index; Bronchial Diseases - epidemiology; Chronic obstructive pulmonary disease; Comorbidity; Control asthma; Cross-Sectional Studies; Cytokines; Disease management; Eosinophilia - epidemiology; Female; Gastroesophageal reflux; Glucocorticoids - therapeutic use; Goals; Humans; IL-8; Inflammation; Interleukin-8 - blood; Male; Medication Adherence; Middle Aged; Nebulizers and Vaporizers; Obesity; Patients; Serum biomarkers; Severe asthma; Severity of Illness Index; Spain - epidemiology; Therapeutic goals; Treatable traits; Spain; Therapeutic goals; Severe asthma; Serum biomarkers; Control asthma; IL-8; Treatable traits
• ISSN: 0954-6111; 1532-3064
• DOI: 10.1016/j.rmed.2019.03.006

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-We have added the following highlights:•It seems reasonable to approach asthma heterogeneity pragmatically, setting specific therapeutic goals for each individual and associating them with treatable traits.•The most common clinical phenotype was late-onset eosinophilic asthma (58.1%) in a population of adult uncontrolled severe asthmatics.•More than half of the patients had not experienced severe exacerbations in the previous year and the most common therapeutic objective was symptom control (71% of the cases).•From a set of serum biomarkers (IgE, IL-5, IL-13, periostin, CCL23, Il-6, IL-8, IL-17, TNFα and IFNγ) only IL-8 was found to be significantly associated with a therapeutic goal: uncontrolled symptoms.