The role of M6A modification in the regulation of tumor-related lncRNAs

• Published in: Molecular therapy. Nucleic acids Vol. 24; pp. 768 - 779
• Main Authors: Lan, Yufei, Liu, Boyang, Guo, Hongbo
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 04-06-2021; American Society of Gene & Cell Therapy; Elsevier
• Subjects: biological function; lncRNA; methylation modification; N6-methyladenosine; Review; tumor; N6-methyladenosine; methylation modification; lncRNA; tumor; biological function
• ISSN: 2162-2531; 2162-2531
• DOI: 10.1016/j.omtn.2021.04.002

N6-methyladenosine (m6A) is the most abundant modification in eukaryotic cells, and it regulates RNA transcription, processing, splicing, degradation, and translation. Long non-coding RNAs (lncRNAs), as transcriptional products with no or limited protein coding ability more than 200 nt in length, play an important role in epigenetic modification, mRNA transcription, splicing, stability, translation, and other biological functions. Extensive studies have shown that both m6A modification and lncRNAs are involved in the pathogenesis of various diseases, such as kinds of cancers, heart failure, Alzheimer’s disease, periodontitis, human abdominal aortic aneurysm, and obesity. To date, m6A modification has been identified as an important biological function in enrichment and regulation of lncRNAs. In this review, we summarize the role of m6A modification in the regulation and function of tumor-related lncRNAs. Moreover, we discuss the potential applications and possible future directions in the field.
[Display omitted]
In this review, we summarize the role of m6A modification in the regulation and function of tumor-related lncRNAs. Moreover, we discuss the potential applications and possible future directions in the field.