Novel Lead-free biocompatible piezoelectric Hydroxyapatite (HA) – BCZT (Ba0.85Ca0.15Zr0.1Ti0.9O3) nanocrystal composites for bone regeneration

• Published in: Nanotechnology reviews (Berlin) Vol. 8; no. 1; pp. 61 - 78
• Main Authors: Manohar, Chelli Sai, Kumar, B Siva, Sadhu, Sai Pavan Prashanth, Srimadh, Sai Krishna, Muthukumar, V Sai, Venketesh, S., Varma, K. B. R.
• Format: Journal Article
• Language: English
• Published: Berlin De Gruyter 01-01-2019; Walter de Gruyter GmbH
• Subjects: Barium; Barium titanates; BCZT; Biocompatibility; Biomedical materials; Body fluids; Bone growth; bone regeneration; Calcium phosphates; Composite materials; Crystal structure; Crystallinity; Deoxidizing; Dwell time; Ferroelectric materials; Ferroelectricity; Hydroxyapatite; In vitro methods and tests; Infrared spectroscopy; Microscopy; Morphology; Nanocrystals; Optimization; Phase transitions; Piezoelectricity; Powder; Raman spectroscopy; Regeneration; Scanning electron microscopy; Spectroscopy; Spectrum analysis; Structural analysis; Surgical implants; Synthesis; Transmission electron microscopy; Tricalcium phosphate
• ISSN: 2191-9097; 2191-9089; 2191-9097
• DOI: 10.1515/ntrev-2019-0006

BCZT (Ba
Ca
Zr
.1Ti
) is a recent class of lead-free ferroelectric material associated with high piezoelectric coefficient, making it suitable to inspire hydroxyapatite (HA)-BCZT ceramics for bone materials. Nano-crystalline hydroxyapatite (HA) synthesized using the hydrothermal route was characterized via FT-IR, Raman spectroscopy, X-ray powder diffraction (XRD), and Scanning Electron Microscopy (SEM). We also rationalized its formation as a function of operating conditions such as dwell time and temperature in this route. The nano-crystalline BCZT powder was synthesized via a sol-gel technique and its structural and morphological characterization were carried out using Raman Spectroscopy, XRD and Transmission Electron Microscopy (TEM). These investigations facilitated the optimization of HA-BCZT compositions and their electrical poling conditions to achieve enhanced piezoelectric effect. The composites (HA-BCZT) sintered at 1350
C exhibited promising piezoelectric properties. We report the enhanced piezoelectric coefficient (d
) of 7±1 pC/N for 50% HA-BCZT which is significant as compared to that reported in the literature for ~98% BT (barium titanate) -HA composites. We highlight the role of Simulated Body Fluid (SBF) on the intriguing phase-change of Tricalcium Phosphate (TCP) obtained at this sintering temperature, to hydroxyapatite for its essential contribution to promote bone growth. We theoretically support the confirmed
biocompatibility of these composites.
: Novel lead-free biocompatible piezoelectric HA-BCZT nanocrystal composites for accelerated Bone regeneration