Vapor-phase deposition-based self-assembled monolayer for an electrochemical sensing platform

• Published in: AIP advances Vol. 10; no. 4; pp. 045213 - 045213-6
• Main Authors: Ahn, Jun Ki, Oh, Seung Jun, Park, Hun, Song, Yesol, Kwon, Seong Jung, Shin, Hang-Beum
• Format: Journal Article
• Language: English
• Published: Melville American Institute of Physics 01-04-2020; AIP Publishing LLC
• Subjects: Biosensors; Deposition; Electrochemical analysis; Gold; Liquid phases; Monolayers; Process parameters; Self-assembled monolayers; Self-assembly; Signal processing; Target detection; Vapors
• ISSN: 2158-3226; 2158-3226
• DOI: 10.1063/1.5144845

Vapor-phase deposition was investigated to prepare electrochemically stable self-assembled monolayers (SAMs) since the promising coating technology can improve the surface functionality for electrochemical biosensors. In our experiments, mercaptopropionic acid (MPA)–Au SAMs in vapor-phase deposition were compared with those in the liquid-phase process, and their electrochemical properties were interrogated by measuring cyclic voltammetry and impedance spectroscopy. As a result, Au–MPA SAMs prepared in a vapor-phase process exhibited much higher electrochemical stability than those in a liquid-phase process. Furthermore, parameters in the vapor–phase deposition process were optimized for reproducible impedance signals, and the as-prepared Au–MPA SAMs under the conditions were adopted for detecting target IgE. It would pave the way for the development of a highly reproducible electrochemical bio-sensing platform.