Dynamic imaging of perfusion in human skeletal muscle during exercise with arterial spin labeling

• Published in: Magnetic resonance in medicine Vol. 42; no. 2; pp. 258 - 267
• Main Authors: Frank, Lawrence R., Wong, Eric C., Haseler, Luke J., Buxton, Richard B.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01-08-1999; Williams & Wilkins
• Subjects: arterial spin labeling; Arteries - anatomy & histology; Biological and medical sciences; Cardiovascular system; Exercise - physiology; functional magnetic resonance imaging; Humans; Investigative techniques, diagnostic techniques (general aspects); Leg - blood supply; Magnetic Resonance Imaging - methods; Male; Medical sciences; muscle blood flow; muscle perfusion; muscle physiology; Muscle, Skeletal - blood supply; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Regional Blood Flow; Sensitivity and Specificity; Space life sciences; Spin Labels; Physical exercise; Human; Volunteer; Experimental study; Striated muscle; Spatial variation; Nuclear magnetic resonance imaging; Time variation; Artery; Spin labelling; Measurement technique; Circulatory system; Hemodynamics
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/(SICI)1522-2594(199908)42:2<258::AID-MRM7>3.0.CO;2-E

MR images acquired by using an arterial spin‐labeling technique showed spatial and temporal variations of perfusion in the skeletal muscle of exercising humans. Perfusion measurements made during plantar flexion exercise in normal volunteers were consistent with those obtained by traditional techniques reported in the literature. Spatial heterogeneity of perfusion values clearly delineated the various muscle groups within the lower leg. These results are interpreted in terms of a quantitative model for the perfusion signal in muscle. This method can provide a useful tool in the study of muscle physiology. Magn Reson Med 42:258–267, 1999. Published 1999 Wiley‐Liss, Inc.