Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation

Mammalian ovarian primordial follicle activation and regulation is considered as one of the most important stages of folliculogenesis and as such requires exquisite control. Selection of quiescent follicles to enter the growing pool determines the rate of supply of maturing follicles over the female...

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Published in:	Journal of cellular physiology Vol. 227; no. 3; pp. 1188 - 1198
Main Authors:	Sutherland, J.M., Keightley, R.A., Nixon, B., Roman, S.D., Robker, R.L., Russell, D.L., McLaughlin, E.A.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-03-2012
Subjects:	Animals Animals, Outbred Strains Cell Line Female Mice Organ Culture Techniques Ovarian Follicle - cytology Ovarian Follicle - growth & development Ovarian Follicle - physiology Primary Cell Culture Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction - drug effects Signal Transduction - physiology Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - metabolism
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Summary:	Mammalian ovarian primordial follicle activation and regulation is considered as one of the most important stages of folliculogenesis and as such requires exquisite control. Selection of quiescent follicles to enter the growing pool determines the rate of supply of maturing follicles over the female reproductive lifespan. To coordinate this process a range of positive and negative input signals contribute to determine follicle fate. This study demonstrates that the cytokine Leukemia Inhibitory Factor (LIF) activates the Janus Kinase 1/Signal Transducers and Activators of Transcription 3 (JAK1/STAT3) signaling pathway in pre‐granulosa cells and positively regulates primordial follicle activation. Negative regulation of the JAK/STAT pathway is controlled by the suppressor of cytokine signaling 4 (SOCS4) protein, which target members of negative feedback loops, Cardiotrophin like Cytokine (CLC), Poly (rC) Binding Protein 1 (PCBP1), and Cytosolic Malate Dehydrogenase (MDH1) to suppress follicle growth and development. J. Cell. Physiol. 227: 1188–1198, 2012. © 2011 Wiley Periodicals, Inc.
Bibliography:	ark:/67375/WNG-JMB735V5-F ArticleID:JCP22837 Australian Research Council Discovery Project - No. DP0878355 istex:6DD25E84B16921350A0CBF1B072B1D777EB0792F ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.22837