Biomonitoring of polycyclic aromatic hydrocarbons in human urine

Measurement of polycyclic aromatic hydrocarbons (PAH) metabolites in human urine is the method of choice to determine occupational and/or environmental exposure of an individual to PAH, in particular, when multiple routes of exposure have to be taken into account. Requirements for methods of biomoni...

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Bibliographic Details
Published in:	Journal of Chromatography B Vol. 778; no. 1; pp. 31 - 47
Main Authors:	Jacob, Jürgen, Seidel, Albrecht
Format:	Book Review Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 05-10-2002
Subjects:	Environmental Monitoring Humans Polycyclic Compounds - pharmacokinetics Polycyclic Compounds - urine Polynuclear aromatic hydrocarbons Polynuclear aromatic hydrocarbons
Online Access:	Get full text
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Summary:	Measurement of polycyclic aromatic hydrocarbons (PAH) metabolites in human urine is the method of choice to determine occupational and/or environmental exposure of an individual to PAH, in particular, when multiple routes of exposure have to be taken into account. Requirements for methods of biomonitoring PAH metabolites in urine are presented. Studies using 1-hydroxypyrene or phenanthrene metabolites including its phenols and dihydrodiols are summarized. The role of these PAH metabolites as established biomarkers and also more recent developments of PAH biomonitoring are discussed.
ISSN:	1570-0232 1873-376X
DOI:	10.1016/S0378-4347(01)00467-4