Characterizing the risk of respiratory syncytial virus in infants with older siblings a population-based birth cohort study

• Published in: Epidemiology and infection Vol. 145; no. 2; pp. 266 - 271
• Main Authors: JACOBY, P., GLASS, K., MOORE, H. C.
• Format: Journal Article
• Language: English
• Published: England Cambridge University Press 01-01-2017
• Subjects: Adult; Babies; Child; Child, Preschool; Cohort analysis; Cohort Studies; Datasets; Disease Transmission, Infectious; Epidemiology; Families & family life; Family Health; Female; Hospitals; Households; Humans; Illnesses; Infant; Infant, Newborn; Infections; Infectious diseases; Laboratories; Linked Data; Male; Midwifery; Native peoples; Population; Respiratory infections; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - epidemiology; Respiratory Syncytial Virus Infections - pathology; Respiratory Syncytial Virus Infections - transmission; Respiratory Syncytial Viruses - isolation & purification; Risk Assessment; Risk factors; Siblings; Urban Population; Vaccines; Viruses; Western Australia - epidemiology; Young Adult; Australia; Western Australia Australia; Torres Strait; Australia, Western Australia, Perth; ISW, Australia, Western Australia; household; Epidemiology; respiratory syncytial virus; vaccine policy development
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268816002545

From a population-based birth cohort of 245 249 children born in Western Australia during 1996–2005, we used linkage of laboratory and birth record datasets to obtain data including all respiratory syncytial virus (RSV) detections during infancy from a subcohort of 87 981 singleton children born in the Perth metropolitan area from 2000 to 2004. Using log binomial regression, we found that the risk of infant RSV detection increases with the number of older siblings, with those having ⩾3 older siblings experiencing almost three times the risk (relative risk 2·83, 95% confidence interval 2·46–3·26) of firstborn children. We estimate that 45% of the RSV detections in our subcohort were attributable to infection from an older sibling. The sibling effect was significantly higher for those infants who were younger during the season of peak risk (winter) than those who were older. Although older siblings were present in our cohort, they had very few RSV detections which could be temporally linked to an infant's infection. We conclude that RSV infection in older children leads to less severe symptoms but is nevertheless an important source of infant infection. Our results lend support to a vaccination strategy which includes family members in order to provide maximum protection for newborn babies.