Imaging of Activated T Cells

The adaptive immune response plays a critical role in detecting, eliminating, and creating a memory toward foreign pathogens and malignant cells. Demonstration of the specific and effective target killing of T cells in cancer has reignited interest in the study and therapeutic manipulation of the in...

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Bibliographic Details
Published in:	Journal of Nuclear Medicine Vol. 64; no. 1; pp. 30 - 33
Main Authors:	Sako, Mohammad O, Larimer, Benjamin M
Format:	Journal Article
Language:	English
Published:	United States Society of Nuclear Medicine 01-01-2023
Subjects:	Adaptive Immunity Cell activation Diagnostic Imaging Focus on Molecular Imaging Humans Immune response Immune system Immunological memory Immunotherapy Lymphocytes Lymphocytes T Monitoring Neoplasms - pathology T-Lymphocytes Tumors cancer T cells PET immunotherapy
Online Access:	Get full text
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Summary:	The adaptive immune response plays a critical role in detecting, eliminating, and creating a memory toward foreign pathogens and malignant cells. Demonstration of the specific and effective target killing of T cells in cancer has reignited interest in the study and therapeutic manipulation of the interaction between tumor and immune system. To both improve therapeutic efficacy and reduce adverse events, accurate monitoring of the activation of T cells is required. Several approaches to monitoring not just the presence, but importantly the activation, of T cells have been developed. Here, we review the recent advances in T-cell activation imaging and future directions for potential implementation into clinical utility.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Published online Dec. 2, 2022.
ISSN:	0161-5505 1535-5667 2159-662X
DOI:	10.2967/jnumed.122.264097