Expression pattern of macrophage migration inhibitory factor during embryogenesis

• Published in: Mechanisms of development Vol. 84; no. 1; pp. 153 - 156
• Main Authors: Kobayashi, Shigetoshi, Satomura, Kazuhito, Levsky, Jeffrey M., Sreenath, Taduru, Wistow, Graeme J., Semba, Ichiro, Shum, Lillian, Slavkin, Harold C., Kulkarni, Ashok B.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-06-1999
• Subjects: Animals; Animals, Newborn; Cytokine; Embryogenesis; Gene Expression Regulation, Developmental; Liver - embryology; Liver - metabolism; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors - genetics; Macrophage Migration-Inhibitory Factors - metabolism; Male; Mesoderm - metabolism; Mice; Muscle Development; Muscle, Skeletal - embryology; Muscle, Skeletal - growth & development; Muscle, Skeletal - metabolism; Muscle, Smooth - embryology; Muscle, Smooth - growth & development; Muscle, Smooth - metabolism; Nervous System - embryology; Nervous System - metabolism; Testis - embryology; Testis - metabolism; Macrophage migration inhibitory factor; Embryogenesis; Cytokine
• ISSN: 0925-4773; 1872-6356
• DOI: 10.1016/S0925-4773(99)00057-X

Although macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine that inhibits the migration of macrophages, its ubiquitous expression suggests it may have a role beyond the immune system. Here we report a detailed characterization of MIF expression during mouse embryogenesis. The MIF expression pattern was found to parallel tissues specification and organogenesis.