Influence of Seropositivity against Adenovirus-36 on the Risk of Obesity and Insulin Resistance in the Child Population of Southern Chile

• Published in: Viruses Vol. 16; no. 6; p. 995
• Main Authors: Brito, Roberto, Sapunar, Jorge, Aguilar-Farías, Nicolás, Navarro-Riquelme, Juan, Pavez, Monica, Hirata, Mario Hiroyuki, Cerda, Alvaro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20-06-2024; MDPI
• Subjects: Adenovirus; Adenovirus diseases; Adenovirus Infections, Human - blood; Adenovirus Infections, Human - epidemiology; Adenovirus Infections, Human - virology; Adenovirus-36; Adenoviruses; Adenoviruses, Human; Adipogenesis; Adolescent; Age; Animal models; Anthropometry; Antibodies; Antibodies, Viral - blood; Body mass index; Body weight; Cell culture; Child; childhood obesity; Children; Chile - epidemiology; Cholesterol; Communicable diseases in children; Complications and side effects; Developmental stages; Female; Glucose; High density lipoprotein; Host-virus relationships; Humans; Insulin - blood; Insulin Resistance; Insulin secretion; Lipids; Male; Metabolic disorders; Nutritional status; Obesity; Obesity - epidemiology; Obesity - virology; Overweight; Pediatric Obesity - epidemiology; Pediatric Obesity - virology; Pediatrics; Prevalence; Risk Factors; Seroepidemiologic Studies; Software; Standard scores; Triglycerides; Variables; Chile; United States > US; insulin resistance; Adenovirus-36; childhood obesity
• ISSN: 1999-4915; 1999-4915
• DOI: 10.3390/v16060995

Previous infection with Adenovirus-36 (HAdv-D36) has been associated with adipogenesis and glycemic regulation in cell culture and animal models. In humans, HAdv-D36 antibodies correlate with increased obesity risk yet paradoxically enhance glycemic control across various demographics. This study assesses the association of HAdv-D36 seropositivity with obesity, lipid, and glycemic profiles among school-aged children.
: We evaluated 208 children aged 9-13, categorized by BMI z-scores into normal weight (-1 to +1), overweight (+1 to +2), and obese (>+3). Assessments included anthropometry, Tanner stage for pubertal development, and biochemical tests (relating to lipids, glucose, and insulin), alongside HAdv-D36 seropositivity checked via ELISA. Insulin resistance was gauged using Chilean pediatric criteria.
: The cohort displayed a high prevalence of overweight/obesity. HAdv-D36 seropositivity was 5.4%, showing no correlation with nutritional status. Additionally, no link between HAdv-D36 seropositivity and lipid levels was observed. Notably, insulin levels and HOMA-RI were significantly lower in HAdv-D36 positive children (
< 0.001). No cases of insulin resistance were reported in the HAdv-D36 (+) group in our population.
: HAdv-D36 seropositivity appears to decrease insulin secretion and resistance, aligning with earlier findings. However, no association with obesity development was found in the child population of southern Chile.