Effect of aging on physical properties of phenylbutazone tablets

A study was made of the influence of age on the physical properties of phenylbutazone tablets BP, with special reference to in vitro dissolution rates. Past batches of tablets showed a progressive decrease in dissolution rate with age. This effect could be simulated in short periods by using elevate...

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Bibliographic Details
Published in:	Journal of pharmaceutical sciences Vol. 64; no. 2; p. 335
Main Authors:	Barrett, D, Fell, J T
Format:	Journal Article
Language:	English
Published:	United States 01-02-1975
Subjects:	Carbohydrates Color Drug Stability Drug Storage Hardness Kinetics Phenylbutazone Solubility Tablets Temperature Time Factors
Online Access:	Get more information
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Summary:	A study was made of the influence of age on the physical properties of phenylbutazone tablets BP, with special reference to in vitro dissolution rates. Past batches of tablets showed a progressive decrease in dissolution rate with age. This effect could be simulated in short periods by using elevated temperatures. The effect appears to be connected with the subcoat layer of the sugar coating of the tablet which adheres more strongly to the tablet core and slows down its disintegration.
ISSN:	0022-3549
DOI:	10.1002/jps.2600640233