Reduction in inflammation in the footpad of carrageenan treated mice following the topical administration of anti-TNF molecules formulated in a micro-emulsion

• Published in: Journal of controlled release Vol. 145; no. 3; pp. 210 - 213
• Main Authors: Himes, R., Lee, S., McMenigall, K., Russell-Jones, G.J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 03-08-2010; Elsevier
• Subjects: Administration, Topical; Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - immunology; Anti-Inflammatory Agents - pharmacokinetics; Anti-Inflammatory Agents - therapeutic use; Anti-TNF; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacokinetics; Antibodies, Monoclonal - therapeutic use; Biological and medical sciences; Carrageenan; Emulsions; Female; General pharmacology; Inflammation - drug therapy; Medical sciences; Mice; Micro-emulsion; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Protein delivery; Skin - metabolism; Topical; Transdermal; Tumor Necrosis Factor-alpha - immunology; Protein delivery; Anti-TNF; Topical; Transdermal; Micro-emulsion; Pharmaceutical technology; Rodentia; Inflammation; Protein; Percutaneous route; Polyelectrolyte; Molecules; Local administration; Vertebrata; Reduction; Mammalia; Emulsion; Mouse; Animal; Oside polymer; Carrageenan; Topical administration
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2010.04.023

Water-in-oil micro-emulsions (ME) have been shown to have the ability to deliver water-soluble peptides and proteins into the skin. Topical administration of these formulations represents an ideal means of device-free delivery of these pharmaceutical agents. Topically administered anti-tumor necrosis factor (TNF) monoclonal antibodies formulated within a water-in-oil micro-emulsion were found to have similar pharmaceutical activity to control formulations that were administered by injection. This form of delivery presents itself as an exciting, pain-free and device-free delivery system for administration of protein pharmaceuticals and as such has enormous potential for the delivery of peptides and protein into the dermal layer of the skin.
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