Choroidal hypertransmission width on optical coherence tomography: a prognostic biomarker in idiopathic macular hole surgery

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 262; no. 8; pp. 2481 - 2489
• Main Authors: Alkabes, Micol, Rabiolo, Alessandro, Govetto, Andrea, Fogagnolo, Paolo, Ranno, Stefano, Marchetti, Mattia, Frerio, Filippo, Wild, Davide, Gatti, Valentina, Muraca, Andrea, De Cillà, Stefano
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2024; Springer Nature B.V
• Subjects: Acuity; Aged; Biomarkers; Choroid - diagnostic imaging; Female; Follow-Up Studies; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Patients; Postoperative Period; Prognosis; Retinal Disorders; Retinal Perforations - diagnosis; Retinal Perforations - physiopathology; Retinal Perforations - surgery; Retrospective Studies; Surgery; Tomography; Tomography, Optical Coherence - methods; Visual acuity; Visual Acuity - physiology; Vitrectomy - methods; Surgical outcomes; Prognostic factor; Minimum diameter; Visual acuity; Macular hole; Pars plana vitrectomy
• ISSN: 0721-832X; 1435-702X; 1435-702X
• DOI: 10.1007/s00417-024-06427-8

Purpose
To test the hypothesis that optical coherence tomography (OCT) choroidal hypertransmission width (CHW) is a prognostic biomarker in idiopathic macular hole (MH) surgery
Methods
Retrospective cohort study of consecutive patients undergoing successful pars plana vitrectomy for idiopathic MH. We collected demographic, clinical, and OCT variables at the preoperative and last available visits. Two investigators assessed the following OCT parameters: MH minimum diameter, base diameter, CHW, ellipsoid zone, and external limiting membrane status (absent vs. present). Delta CHW was calculated as the difference between CHW and MH minimum diameter. Linear models were used to investigate factors associated with postoperative best-corrected visual acuity (BCVA) and BCVA change.
Results
Thirty-six eyes (36 patients) with a median (interquartile range (IQR)) follow-up of 9 (8–11) months were included. The median BCVA (IQR) improved from 0.75 (1–0.6) logMAR preoperatively to 0.2 (0.6–0.1) logMAR at the last visit (
p
< 0.001). Preoperative MH minimum diameter (for a 10-μm increase, estimate (standard error (SE)): 0.009 (0.003) logMAR,
p
= 0.003), base diameter (for a 10-μm increase, 0.003 (0.001) logMAR,
p
= 0.032), CHW (for a 10-μm increase, 0.008 (0.002) logMAR,
p
< 0.001), and delta CHW (for a 10-μm increase, 0.013 (0.005) logMAR,
p
= 0.009) were significantly associated with postoperative BCVA. The proportion of variance explained was the highest for MH CHW (
R
2
0.35), followed by minimum MH diameter (
R
2
0.24), delta CHW (
R
2
0.19), and MH base diameter (
R
2
0.14). None of the study variables was associated with delta BCVA.
Conclusion
Preoperative CHW is associated with postoperative visual acuity in patients undergoing successful idiopathic MH surgery and may be a useful OCT prognostic biomarker.