The MAOA , COMT, MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women

• Published in: Maturitas Vol. 84; pp. 42 - 54
• Main Authors: Różycka, Agata, Słopień, Radosław, Słopień, Agnieszka, Dorszewska, Jolanta, Seremak-Mrozikiewicz, Agnieszka, Lianeri, Margarita, Maciukiewicz, Małgorzata, Warenik-Szymankiewicz, Alina, Grzelak, Teresa, Kurzawińska, Grażyna, Drews, Krzysztof, Klejewski, Andrzej, Jagodziński, Paweł P
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-02-2016
• Subjects: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics; Adult; Aged; Catechol O-Methyltransferase - genetics; COMT; Depression - genetics; Depressive Disorder - genetics; ESR1; Estrogen Receptor alpha - genetics; Female; Gene polymorphism; Genotype; Humans; Internal Medicine; MAOA; Menopausal depression; Menopause - psychology; Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Minor Histocompatibility Antigens; Monoamine Oxidase - genetics; MTHFR; Norepinephrine Plasma Membrane Transport Proteins - genetics; Obstetrics and Gynecology; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Receptor, Serotonin, 5-HT1B - genetics; Receptor, Serotonin, 5-HT2A - genetics; Receptor, Serotonin, 5-HT2C - genetics; Receptors, GABA-A - genetics; Risk Factors; Tryptophan Hydroxylase - genetics; MTHFR; COMT; MAOA; ESR1; Gene polymorphism; Menopausal depression
• ISSN: 0378-5122; 1873-4111
• DOI: 10.1016/j.maturitas.2015.10.011

Highlights • We found associations between the MAOA c.1460C > T, COMT c.472G > A, MTHFR c.677C > T and ESR1 454-351 A > G polymorphisms to mild and moderate depressive symptoms in menopausal women. • No significant differences were observed in either the frequencies of the genotypes or alleles between the patients and the controls in the polymorphic variants of the 5HTR2A , 5HTR1B , 5HTR2C , TPH1 , TPH2 , COMT , NET , GABRB1 , MTR and MTHFD1 genes. • This is an innovative study presenting a new research area and suggesting a direction for further investigation in genetics of depression in women during midlife.