Differential effects produced by ketamine on oscillatory activity recorded in the rat hippocampus, dorsal striatum and nucleus accumbens

• Published in: Journal of psychopharmacology (Oxford) Vol. 25; no. 6; pp. 808 - 821
• Main Authors: Hunt, Mark J, Falinska, Monika, Łęski, Szymon, Wójcik, Daniel K, Kasicki, Stefan
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-06-2011; Sage Publications; Sage Publications Ltd
• Subjects: Adult and adolescent clinical studies; Amphetamines; Anatomy; Animal behavior; Animals; Biological and medical sciences; Brain; Brain architecture; Brain Waves - drug effects; Brain Waves - physiology; Caudate-putamen; Corpus Striatum - drug effects; Corpus Striatum - physiology; Excitatory Amino Acid Antagonists - pharmacology; Glutamic acid receptors (ionotropic); Hippocampus; Hippocampus - drug effects; Hippocampus - physiology; Ketamine; Ketamine - pharmacology; Male; Medical sciences; N-Methyl-D-aspartic acid receptors; Neostriatum; Neuropharmacology; Nucleus accumbens; Nucleus Accumbens - drug effects; Nucleus Accumbens - physiology; Oscillations; Pharmacology. Drug treatments; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Rats; Rats, Wistar; Ripples; Rodents; Schizophrenia; synchronization; nucleus accumbens; schizophrenia; ketamine; Hippocampus; Rat; Rodentia; Central nervous system; Schizophrenia; Dorsal nucleus; Basal ganglion; Glutamate receptor; Corpus striatum; Synchronization; Encephalon; Psychosis; Nucleus accumbens; Vertebrata; Mammalia; Ketamine; General anesthetic; Animal; Drug of abuse; Antagonist; NMDA receptor
• ISSN: 0269-8811; 1461-7285
• DOI: 10.1177/0269881110362126

Previously, we showed that NMDA antagonists enhance high-frequency oscillations (130–180 Hz) in the nucleus accumbens. However, whether NMDA antagonists can enhance high-frequency oscillations in other brain regions remains unclear. Here, we used monopolar, bipolar and inverse current source density techniques to examine oscillatory activity in the hippocampus, a region known to generate spontaneous ripples (∼200 Hz), its surrounding tissue, and the dorsal striatum, neuroanatomically related to the nucleus accumbens. In monopolar recordings, ketamine-induced increases in the power of high-frequency oscillations were detected in all structures, although the power was always substantially larger in the nucleus accumbens. In bipolar recordings, considered to remove common-mode input, high-frequency oscillations associated with ketamine injection were not present in the regions we investigated outside the nucleus accumbens. In line with this, inverse current source density showed the greatest changes in current to occur in the vicinity of the nucleus accumbens and a monopolar structure of the generator. We found little spatial localisation of ketamine high-frequency oscillations in other areas. In contrast, sharp-wave ripples, which were well localized to the hippocampus, occurred less frequently after ketamine. Notably, we also found ketamine produced small, but significant, changes in the power of 30–90 Hz gamma oscillations (an increase in the hippocampus and a decrease in the nucleus accumbens).