Genetic Maps of Polymorphic DNA Loci on Rat Chromosome 1

• Published in: Genomics (San Diego, Calif.) Vol. 36; no. 2; pp. 320 - 327
• Main Authors: Ding, Yan-Ping, Remmers, Elaine F., Du, Ying, Longman, Ryan E., Goldmuntz, Ellen A., Zha, Hongbin, Kotake, Shigeru, Cannon, Grant W., Griffiths, Marie M., Wilder, Ronald L.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01-09-1996; Elsevier
• Subjects: Animals; Biological and medical sciences; Chromosome Mapping; Chromosomes; Classical genetics, quantitative genetics, hybrids; DNA; Female; Fundamental and applied biological sciences. Psychology; Genetic Markers; Genetics of eukaryotes. Biological and molecular evolution; Male; Microsatellite Repeats; Polymorphism, Genetic; Rats; Rats, Inbred F344; Rats, Inbred Lew; Vertebrata; Genetic mapping; Vertebrata; Mammalia; Restriction fragment length polymorphism; Gene; Genetic marker; Rat; Microsatellite DNA; Rodentia; Homology; Chromosome 1; Polymorphism
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1996.0468

Genetic linkage maps of loci defined by polymorphic DNA markers on rat chromosome 1 were constructed by genotyping F2 progeny of F344/N × LEW/N, BN/SsN × LEW/N, and DA/Bkl × F344/Hsd inbred rat strains. In total, 43 markers were mapped, of which 3 were restriction fragment length polymorphisms and the others were simple sequence length polymorphisms. Nineteen of these markers were associated with genes. Six markers for five genes, γ-aminobutyric acid receptor β3 (Gabrb3), syntaxin 2 (Stx2), adrenergic receptor β1 (Adrb1), carcinoembryonic antigen gene family member 1 (Cgm1), and lipogenic protein S14 (Lpgp), and 20 anonymous loci were not previously reported. Thirteen gene loci (Myl2, Aldoa, Tnt, Igf2, Prkcg, Cgm4, Calm3, Cgm3, Psbp1, Sa, Hbb, Ins1,andTcp1) were previously mapped. Comparative mapping analysis indicated that a large portion of rat chromosome 1 is homologous to mouse chromosome 7, although the homologs of two rat genes are located on mouse chromosomes 17 and 19. Homologs of the rat chromosome 1 genes that we mapped are located on human chromosomes 6, 10, 11, 12, 15, 16, and 19.