Associations between thalamocortical functional connectivity and sensory over-responsivity in infants at high likelihood for ASD

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 33; no. 12; pp. 8075 - 8086
• Main Authors: Wagner, Lauren, Banchik, Megan, Okada, Nana J, McDonald, Nicole, Jeste, Shafali S, Bookheimer, Susan Y, Green, Shulamite A, Dapretto, Mirella
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 08-06-2023
• Subjects: Autism Spectrum Disorder; Basal Ganglia; Humans; Infant; Magnetic Resonance Imaging; Original; Probability; Thalamus; fMRI; infancy; functional connectivity; autism; thalamus
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhad100

Abstract
Despite growing evidence implicating thalamic functional connectivity atypicalities in autism spectrum disorder (ASD), it remains unclear how such alterations emerge early in human development. Because the thalamus plays a critical role in sensory processing and neocortical organization early in life, its connectivity with other cortical regions could be key for studying the early onset of core ASD symptoms. Here, we investigated emerging thalamocortical functional connectivity in infants at high (HL) and typical (TL) familial likelihood for ASD in early and late infancy. We report significant thalamo-limbic hyperconnectivity in 1.5-month-old HL infants, and thalamo-cortical hypoconnectivity in prefrontal and motor regions in 9-month-old HL infants. Importantly, early sensory over-responsivity (SOR) symptoms in HL infants predicted a direct trade-off in thalamic connectivity whereby stronger thalamic connectivity with primary sensory regions and basal ganglia was inversely related to connectivity with higher order cortices. This trade-off suggests that ASD may be characterized by early differences in thalamic gating. The patterns reported here could directly underlie atypical sensory processing and attention to social vs. nonsocial stimuli observed in ASD. These findings lend support to a theoretical framework of ASD whereby early disruptions in sensorimotor processing and attentional biases early in life may cascade into core ASD symptomatology.