An herbal medicine prescription (Oreongsan) developed as a new alternative treatment in patients with chronic subdural hematoma: a narrative review

An herbal medicine prescription, Oreongsan (ORS), which is composed of Polyporus, Alismatis Rhizoma, Atractylodis Rhizoma, Poria (Hoelen), and Cinnamomi Cortex Spissus, has been used as treatment in patients with various symptoms such as thirst, diminished urination, edema, hangover, and diarrhea. O...

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Published in:Integrative medicine research Vol. 8; no. 1; pp. 26 - 30
Main Authors: Kwon, Seungwon, Jin, Chul, Cho, Ki-Ho
Format: Journal Article
Language:English
Published: Elsevier B.V 01-03-2019
Elsevier
한국한의학연구원
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Summary:An herbal medicine prescription, Oreongsan (ORS), which is composed of Polyporus, Alismatis Rhizoma, Atractylodis Rhizoma, Poria (Hoelen), and Cinnamomi Cortex Spissus, has been used as treatment in patients with various symptoms such as thirst, diminished urination, edema, hangover, and diarrhea. ORS is the representative prescription of the ’inducing diuresis’ (isu) effect, which traditionally means the effect of controlling the water balance. Advancement of modern science has enabled the determination of the action mechanism of herbal medicine complexes. As a result, ORS has been used in the treatment of patients with chronic subdural hematoma (CSDH), representing a novel indication. ORS inhibits the upregulation of aquaporin-4, which is involved in the development of brain edema in the central nervous system. Both aquaporin-1 and aquaporin-4 are expressed in the outer membrane of the CSDH; through its effect as aquaporin-4 inhibitor, ORS prevents the inflow of fluid into the hematoma, thereby preventing the development and recurrence of hematoma. In this study, we reviewed the relationship between the inducing diuresis effect of ORS and aquaporin, conservative treatment approach in patients with CSDH, and the prevention of recurrence in patients undergoing combined burr hole surgery and treatment with ORS.
Bibliography:These authors contributed equally to this work as first authors.
https://www.sciencedirect.com/science/article/pii/S2213422018302750
ISSN:2213-4220
2213-4239
DOI:10.1016/j.imr.2018.11.003