A case of olfactory ganglioneuroblastoma in a dog: immunohistochemical comparison with olfactory neuroepithelia and olfactory neuroblastomas

• Published in: Journal of Veterinary Medical Science Vol. 86; no. 8; pp. 850 - 854
• Main Authors: YOSHIDA, Kio, CHAMBERS, James K, ITO, Kei, HIRAO, Hidehiro, NIBE, Kazumi, UCHIDA, Kazuyuki
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01-01-2024; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; Cytokeratin; dog; Dog Diseases - pathology; Dogs; Esthesioneuroblastoma, Olfactory - pathology; Esthesioneuroblastoma, Olfactory - veterinary; ganglioneuroblastoma; Ganglioneuroblastoma - pathology; Ganglioneuroblastoma - veterinary; Glial fibrillary acidic protein; Immunohistochemistry - veterinary; nasal tumor; Neuroblasts; Nose Neoplasms - pathology; Nose Neoplasms - veterinary; olfactory neuroblastoma; Olig2 protein; Pathology; Stroma; Synaptophysin; Tubulin; Tumor cells; Tumors; Tyrosine 3-monooxygenase; ganglioneuroblastoma; nasal tumor; olfactory neuroblastoma; dog
• ISSN: 0916-7250; 1347-7439; 1347-7439
• DOI: 10.1292/jvms.24-0181

In the present study, histopathological and immunohistochemical findings of olfactory ganglioneuroblastoma in a dog were compared to those of canine olfactory neuroepithelia and neuroblastomas. Olfactory ganglioneuroblastoma consists of ganglion cell-like tumor cells with Schwannian stroma and neuroblast-like tumor cells. Immunohistochemically, ganglion cell-like tumor cells were immunopositive for synaptophysin, β3-tubulin, and tyrosine hydroxylase, Schwannian stroma was immunopositive for GFAP and SOX2, and neuroblast-like tumor cells were immunopositive for OLIG2, β3-tubulin, SOX2, cytokeratin AE1/AE3, and p63. The immunohistochemical results of olfactory neuroepithelia and olfactory neuroblastomas were similar to those of neuroblast-like tumor cells. These results suggest that the ganglion cell-like tumor cells in the present case have a sympathetic neuron immunophenotype, whereas neuroblast-like tumor cells have an olfactory neuroepithelial immunophenotype.