Transitional liver cell tumors (TLCT) in older children and adolescents: A novel group of aggressive hepatic tumors expressing beta-catenin

• Published in: Medical and pediatric oncology Vol. 39; no. 5; pp. 510 - 518
• Main Authors: Prokurat, Andrzej, Kluge, Przemysław, Kościesza, Andrzej, Perek, Danuta, Kappeler, Andreas, Zimmermann, Arthur
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01-11-2002
• Subjects: Adolescent; beta Catenin; Carcinoma, Transitional Cell - diagnostic imaging; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Cell Transformation, Neoplastic; Child; Cytoskeletal Proteins - metabolism; Female; hepatoblastoma; Hepatoblastoma - diagnostic imaging; Hepatoblastoma - metabolism; Hepatoblastoma - pathology; hepatocellular carcinoma; Humans; Immunohistochemistry; liver cell tumors; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; pediatric liver tumors; Tomography, X-Ray Computed; Trans-Activators - metabolism; transitional liver cell tumor
• ISSN: 0098-1532; 1096-911X
• DOI: 10.1002/mpo.10177

Background
We encountered on seven malignant hepatocellular tumors developing in older children and adolescents.
Results
These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis.
Conclusion
We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions. Med Pediatr Oncol 2002;39:510–518. © 2002 Wiley‐Liss, Inc.