Acquired FVII Deficiency and Acute Myeloid Leukemia: A Case Report and Literature Review

Abstract Factor VII (FVII) deficiency is the most common among all rare inherited bleeding disorders. However, acquired FVII deficiency (aFVIID) is uncommon. Only few cases in the literature have been reported. Herein, we present a case of an aFVIID associated with acute myeloid leukemia (AML), alon...

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Bibliographic Details
Published in:Laboratory medicine Vol. 53; no. 5; pp. e120 - e122
Main Authors: Hammami, Emna, Borgi, Wijden El, Lakhal, Fatma Ben, Salem, Sarra Fekih, Neji, Hend Ben, Gouider, Emna
Format: Journal Article
Language:English
Published: US Oxford University Press 01-09-2022
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Summary:Abstract Factor VII (FVII) deficiency is the most common among all rare inherited bleeding disorders. However, acquired FVII deficiency (aFVIID) is uncommon. Only few cases in the literature have been reported. Herein, we present a case of an aFVIID associated with acute myeloid leukemia (AML), along with a literature review regarding this condition. A 50 year old Arab male patient was diagnosed with AML at the hematology department of our institution. At admission, coagulation tests showed a prolonged prothrombin time (PT) with a normal activated partial thromboplastin time (aPTT) and a slightly elevated fibrinogen level. Prothrombin complex coagulation factors dosing (PCCFD) revealed a decrease only in FVII levels. The patient, however, did not experience any bleeding. The evolution of the health of the patient was marked by a normalization of PT and FVII levels and complete remission.
Bibliography:ObjectType-Case Study-2
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ISSN:0007-5027
1943-7730
DOI:10.1093/labmed/lmab120