Effects of Histochrom and Emoxypin on Biophysical Properties of Electroexitable Cells

• Published in: Bulletin of experimental biology and medicine Vol. 147; no. 2; pp. 196 - 200
• Main Authors: Mischenko, N. P, Fedoreev, S. A, Zapara, T. A, Ratushnyak, A. S
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01-02-2009; Springer US; Springer Nature B.V
• Subjects: Animals; Antioxidants - pharmacology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Electrophysiology; emoxypin; histochrom; Internal Medicine; ion currents; isolated neurons from shell Lymnaea stagnalis; Laboratory Medicine; Lymnaea - cytology; Lymnaea stagnalis; membrane potential; Membrane Potentials - drug effects; Naphthoquinones - pharmacology; Neurons - drug effects; Pathology; Picolines - pharmacology; histochrom; isolated neurons from shell Lymnaea stagnalis; ion currents; emoxypin; membrane potential
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-009-0473-7

Comparative investigation of effects of antioxidant agents histochrom and emoxypin on biophysical characteristics of isolated neurons from shell Lymnaea stagnalis under normal conditions and during oxidative stress was performed. Differently directed effects of these compounds on resting potential and transmembrane ion currents of neural cells under normal conditions were detected. Histochrom provides hyperpolarizing and emoxypin -- depolarizing effect on neuronal membrane potential. Under conditions of oxidative stress both products possess antioxidant action. Obtained data allows coming closer to understanding of cellular-molecular mechanisms of protective action of compounds.