A Neural Signature of Parkinsonism in Patients With Schizophrenia Spectrum Disorders: A Multimodal MRI Study Using Parallel ICA

• Published in: Schizophrenia bulletin Vol. 46; no. 4; pp. 999 - 1008
• Main Authors: Wolf, Robert C, Rashidi, Mahmoud, Fritze, Stefan, Kubera, Katharina M, Northoff, Georg, Sambataro, Fabio, Calhoun, Vince D, Geiger, Lena S, Tost, Heike, Hirjak, Dusan
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 08-07-2020
• Subjects: Adult; Cerebellum - diagnostic imaging; Cerebellum - physiopathology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiopathology; Comorbidity; Connectome; Female; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Neuroimaging; Parkinsonian Disorders - diagnostic imaging; Parkinsonian Disorders - epidemiology; Parkinsonian Disorders - pathology; Parkinsonian Disorders - physiopathology; Principal Component Analysis; Psychotic Disorders - diagnostic imaging; Psychotic Disorders - epidemiology; Psychotic Disorders - pathology; Psychotic Disorders - physiopathology; Regular; Schizophrenia - diagnostic imaging; Schizophrenia - epidemiology; Schizophrenia - pathology; Schizophrenia - physiopathology; Thalamus - diagnostic imaging; Thalamus - physiopathology; schizophrenia; parkinsonism; motor abnormalities; MRI
• ISSN: 0586-7614; 1745-1701
• DOI: 10.1093/schbul/sbaa007

Abstract
Motor abnormalities in schizophrenia spectrum disorders (SSD) have increasingly attracted scientific interest in the past years. However, the neural mechanisms underlying parkinsonism in SSD are unclear. The present multimodal magnetic resonance imaging (MRI) study examined SSD patients with and without parkinsonism, as defined by a Simpson and Angus Scale (SAS) total score of ≥4 (SAS group, n = 22) or <4 (non-SAS group, n = 22). Parallel independent component analysis (p-ICA) was used to examine the covarying components among gray matter volume maps computed from structural MRI (sMRI) and fractional amplitude of low-frequency fluctuations (fALFF) maps computed from resting-state functional MRI (rs-fMRI) patient data. We found a significant correlation (P = .020, false discovery rate [FDR] corrected) between an sMRI component and an rs-fMRI component, which also significantly differed between the SAS and non-SAS group (P = .042, z = −2.04). The rs-fMRI component comprised the cortical sensorimotor network, and the sMRI component included predominantly a frontothalamic/cerebellar network. Across the patient sample, correlations adjusted for the Positive and Negative Syndrome Scale (PANSS) total scores showed a significant relationship between tremor score and loadings of the cortical sensorimotor network, as well as between glabella-salivation score, frontothalamic/cerebellar and cortical sensorimotor network loadings. These data provide novel insights into neural mechanisms of parkinsonism in SSD. Aberrant bottom-up modulation of cortical motor regions may account for these specific motor symptoms, at least in patients with SSD.