Chronic hepatitis B infection is not associated with increased risk of vascular mortality while having an association with metabolic syndrome

• Published in: Journal of medical virology Vol. 88; no. 7; pp. 1230 - 1237
• Main Authors: Katoonizadeh, Aezam, Ghoroghi, Shima, Sharafkhah, Maryam, Khoshnia, Masoud, Mirzaei, Samaneh, Shayanrad, Amaneh, Poustchi, Hossein, Malekzadeh, Reza
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01-07-2016; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; chronic hepatitis B; Cohort Studies; Female; Hepatitis; Hepatitis B virus; Hepatitis B, Chronic - complications; Hepatitis B, Chronic - epidemiology; Hepatitis B, Chronic - mortality; Hepatitis B, Chronic - virology; Humans; Iran - epidemiology; Logistic Models; Longitudinal Studies; Male; Metabolic syndrome; Metabolic Syndrome - etiology; Middle Aged; Mortality; Population Surveillance; Proportional Hazards Models; Risk Factors; Vascular Diseases - etiology; Vascular Diseases - mortality; Vascular Diseases - physiopathology; vascular related mortality; Virology; chronic hepatitis B; metabolic syndrome; vascular related mortality
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.24466

This study aimed to assess the association of chronic hepatitis B (CHB) with vascular mortality and metabolic syndrome (MS) using data from a large population‐based cohort study in Iran. A total of 12,781 participants (2249 treatment‐naïve CHB and 10,532 without CHB) were studied. Logistic regression model was used to assess the association between MS and CHB with adjustment for age, ALT, PLT, alcohol intake, smoking, exercise, and socioeconomic status. MS was defined according to the ATPIII guidelines. Cox proportional hazards model was used to assess the hazard ratios for overall and vascular related mortality. There was a significant association between CHB infection and overall mortality (hazard ratio (95%CI) of 1.44 (1.16–1.79), P < 0.001) after adjusting for other confounders. However, we found no association between CHB infection and mortality from vascular events (hazard ratio (95%CI) of 1.31 (0.93–1.84), P = 0.124) even after subgroup analysis by ALT. Furthermore, increased risk of overall mortality in CHB infected individuals was not related to MS and vice versa (P for interaction = 0.06). We noted a significant direct association between CHB infection and MS in women (OR (95%CI); 1.23 (1.07–1.42), P < 0.004). However, CHB was inversely associated with MS in men (OR (95%CI), 0.85 (0.79–0.99). This gender dependent association was related to high BP levels in women. In this study no association between CHB infection and mortality from vascular events was found. Further longitudinal studies should be done to investigate the exact impact of HBV infection on metabolic parameters and vascular pathology. J. Med. Virol. 88:1230–1237, 2016. © 2016 Wiley Periodicals, Inc.