Serotonergic projections to the caudal brain stem: a double label study using horseradish peroxidase and serotonin immunocytochemistry

Cells of origin of serotonergic and non-serotonergic projections to the caudal brain stem in the primate were examined using a double label technique. Following HRP injections into medullary raphe nuclei and the adjacent reticular formation double labeled cells were found in the dorsal raphe nucleus...

Full description

Saved in:

Bibliographic Details
Published in:	Brain research Vol. 239; no. 1; p. 258
Main Authors:	Yezierski, R P, Bowker, R M, Kevetter, G A, Westlund, K N, Coulter, J D, Willis, W D
Format:	Journal Article
Language:	English
Published:	Netherlands 06-05-1982
Subjects:	Afferent Pathways - anatomy & histology Animals Axonal Transport Brain Stem - anatomy & histology Horseradish Peroxidase Macaca fascicularis Raphe Nuclei - anatomy & histology Serotonin - analysis
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Cells of origin of serotonergic and non-serotonergic projections to the caudal brain stem in the primate were examined using a double label technique. Following HRP injections into medullary raphe nuclei and the adjacent reticular formation double labeled cells were found in the dorsal raphe nucleus, the central superior nucleus and the ventrolateral tegmentum. Retrogradely labeled cells that did not stain for serotonin-like immunoreactivity were found primarily in the periaqueductal gray (PAG) and the mesencephalic and pontine reticular formation. The results are discussed in relation to the descending pathway(s) mediating the effects of PAG stimulation.
ISSN:	0006-8993
DOI:	10.1016/0006-8993(82)90848-4