Perspective insights into versatile hydrogels for stroke: From molecular mechanisms to functional applications

• Published in: Biomedicine & pharmacotherapy Vol. 173; p. 116309
• Main Authors: Wu, Xinghan, Zhang, Tiejun, Jia, Jing, Chen, Yining, Zhang, Ying, Fang, Zhenwei, Zhang, Chenyu, Bai, Yang, Li, Zhengjun, Li, Yuwen
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-04-2024; Elsevier
• Subjects: Biomaterials; Hydrogel; Molecular mechanisms; Stroke; Stroke; Hydrogel; Molecular mechanisms; Biomaterials
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2024.116309

As the leading killer of life and health, stroke leads to limb paralysis, speech disorder, dysphagia, cognitive impairment, mental depression and other symptoms, which entail a significant financial burden to society and families. At present, physiology, clinical medicine, engineering, and materials science, advanced biomaterials standing on the foothold of these interdisciplinary disciplines provide new opportunities and possibilities for the cure of stroke. Among them, hydrogels have been endowed with more possibilities. It is well-known that hydrogels can be employed as potential biosensors, medication delivery vectors, and cell transporters or matrices in tissue engineering in tissue engineering, and outperform many traditional therapeutic drugs, surgery, and materials. Therefore, hydrogels become a popular scaffolding treatment option for stroke. Diverse synthetic hydrogels were designed according to different pathophysiological mechanisms from the recently reported literature will be thoroughly explored. The biological uses of several types of hydrogels will be highlighted, including pro-angiogenesis, pro-neurogenesis, anti-oxidation, anti-inflammation and anti-apoptosis. Finally, considerations and challenges of using hydrogels in the treatment of stroke are summarized.
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•Hydrogels can play a role in stroke treatment by pro-angiogenesis, pro-neurogenesis, anti-oxidation, anti-inflammation and anti-apoptosis.•Hydrogel treatments have significant potential in treating ferroptosis, blood toxicity, reactive gliosis, and mitochondrial dysfunction following a stroke.•Hydrogels can provide significant benefits in individual and clinical stroke treatment.