On the biosynthesis and metabolism of N-acylethanolamine phospholipids in infarcted dog heart

• Published in: Biochimica et biophysica acta Vol. 664; no. 2; p. 445
• Main Authors: Natarajan, V, Reddy, P V, Schmid, P C, Schmid, H H
• Format: Journal Article
• Language: English
• Published: Netherlands 22-05-1981
• Subjects: Acylation; Animals; Dogs; Ethanolamines - metabolism; Fatty Acids - metabolism; Ligation; Male; Metabolism; Myocardial Infarction - metabolism; Myocardium - metabolism; Phosphatidylethanolamines - metabolism; Phospholipids
• ISSN: 0006-3002
• DOI: 10.1016/0005-2760(81)90067-9

Minced tissues from both infarcted and apparently normal areas of canine myocardium 6 h after ligation of the left descending branch of the coronary artery were incubated with [1,2-(14)C]ethanolamine. In each case substantial amounts of radioactivity were incorporated into both phosphatidylethanolamine and N-acylphosphatidylethanolamine. Incubation of homogenates from the same tissues with N-[1-(14)C]palmitoyl phosphatidylethanolamine yielded labeled N-palmitoyl ethanolamine. The data support the concept that N-acylethanolamines, pharmacologically active compounds which accumulate in infarcted myocardium, are produced by N-acylation of ethanolamine phospholipids followed by phosphodiesterase action.