General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald-Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles

An efficient access to the novel 5-(het)arylamino-1,2,3-triazole derivatives has been developed. The method is based on Buchwald-Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines, respectively. As result, it was found that palladium complex [(THP-...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 27; no. 6; p. 1999
Main Authors:	Gribanov, Pavel S, Philippova, Anna N, Topchiy, Maxim A, Minaeva, Lidiya I, Asachenko, Andrey F, Osipov, Sergey N
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 20-03-2022 MDPI
Subjects:	Amination Amines Azide carbene ligands Catalysis Catalysts Chemical reactions Chemistry Chromatography Cross coupling Halides heterocycles Ligands Palladium Triazoles Germany cross-coupling triazoles palladium amination heterocycles carbene ligands
Online Access:	Get full text
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Summary:	An efficient access to the novel 5-(het)arylamino-1,2,3-triazole derivatives has been developed. The method is based on Buchwald-Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines, respectively. As result, it was found that palladium complex [(THP-Dipp)Pd(cinn)Cl] bearing expanded-ring -heterocyclic carbene ligand is the most active catalyst for the process to afford the target molecules in high yields.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules27061999