Natural products as glycolytic inhibitors for cervical cancer treatment: A comprehensive review

• Published in: Biomedicine & pharmacotherapy Vol. 175; p. 116708
• Main Authors: Liu, Qun, Chen, Xiuhan, Tan, Yurong, Liu, Jiao, Zhu, Mingya, Li, Delin, Zhou, Yijie, Zhang, Tiane, Yin, Qiao zhi
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-06-2024; Elsevier
• Subjects: Animals; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Biological Products - pharmacology; Biological Products - therapeutic use; Cervical cancer; Female; Glycolysis; Glycolysis - drug effects; Humans; Mechanism; Natural products; Signal Transduction - drug effects; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - metabolism; Warburg effect; G3P; ENO1; Cyclin D1; HK2; 20S-GRh2; IGF1R; UcA1; RACK1; PFK1; PGLS; PDK1; Warburg effect; DHA, DIM; P-gp; ISCC; SiHa; CIN; MED; AP2α; 1; MEK; ShRNA; PKM; TCA; MMP-2; AMPK; TMBIM6; VDAC1; AR-A; DNAJC8; ALDOA; GAPDH; MMP-9; NTB; Cervical cancer; ERK; Myo1b; ARS; Lnc-TDRG1; LKB1; LPS; PDC; Mechanism; CSCC; HPV; PPP; STIP1; LDHA; MCT4; FX11; PDH; Sp1; TIG1; M6A; Pak4; CC; G6P; STAT5A; G3PD; TIGAR; PDHA1; HIF; PSB-P2; GLUT; SEMA4C; PYR; 2-DG; AKT; F-2; TIIA; POU2F2; SchB; MTOR; STAT; OGDC; HIV; PI3k; R13; Natural products; Bax; I3C; MDM2; Glycolysis; PEP; PK; ATP; FRA1
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.116708

Cervical cancer, a prevalent gynaecological malignancy, presents challenges in late-stage treatment efficacy. Aerobic glycolysis, a prominent metabolic trait in cervical cancer, emerges as a promising target for novel drug discovery. Natural products, originating from traditional medicine, represent a significant therapeutic avenue and primary source for new drug development. This review explores the regulatory mechanisms of glycolysis in cervical cancer and summarises natural compounds that inhibit aerobic glycolysis as a therapeutic strategy. The glycolytic phenotype in cervical cancer is regulated by classical molecules such as HIF-1, HPV virulence factors and specificity protein 1, which facilitate the Warburg effect in cervical cancer. Various natural products, such as artemisinin, shikonin and kaempferol, exert inhibitory effects by downregulating key glycolytic enzymes through signalling pathways such as PI3K/AKT/HIF-1α and JAK2/STAT3. Despite challenges related to drug metabolism and toxicity, these natural compounds provide novel insights and promising avenues for cervical cancer treatment.
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