Cannabidiol and its application in the treatment of oral diseases: therapeutic potentials, routes of administration and prospects

• Published in: Biomedicine & pharmacotherapy Vol. 176; p. 116271
• Main Authors: Hu, Zonghao, Qin, Zishun, Xie, Jinhong, Qu, Yue, Yin, Lihua
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-07-2024; Elsevier
• Subjects: Animals; Cannabidiol (CBD); Cannabidiol - administration & dosage; Cannabidiol - therapeutic use; Drug Administration Routes; Humans; Mouth Diseases - drug therapy; Oral diseases; Pharmacological effects; Routes of administration; Therapeutic potential; Routes of administration; Oral diseases; Pharmacological effects; Therapeutic potential; Cannabidiol (CBD)
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.116271

Cannabidiol (CBD), one of the most important active ingredients in cannabis, has been reported to have some pharmacological effects such as antibacterial and analgesic effects, and to have therapeutic potential in the treatment of oral diseases such as oral cancer, gingivitis and periodontal diseases. However, there is a lack of relevant systematic research and reviews. Therefore, based on the etiology and clinical symptoms of several common oral diseases, this paper focuses on the therapeutic potential of CBD in periodontal diseases, pulp diseases, oral mucosal diseases, oral cancer and temporomandibular joint diseases. The pharmacological effects of CBD and the distribution and function of its receptors in the oral cavity are also summarized. In order to provide reference for future research and further clinical application of CBD, we also summarize several possible routes of administration and corresponding characteristics. Finally, the challenges faced while applying CBD clinically and possible solutions are discussed, and we also look to the future.
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•The functional receptors of CBD and their distribution in oral cavity are briefly reviewed.•The potentials of CBD in the treatment of several oral diseases are summarized.•The administration routes of CBD are introduced to provide reference for the treatment of oral diseases.•The challenges, related solutions and prospects of clinically applying CBD are discussed.