Effect of diesel exhaust particles on renal vascular responses in rats with chronic kidney disease

• Published in: Environmental toxicology Vol. 32; no. 2; pp. 541 - 549
• Main Authors: Al Suleimani, Y. M., Al Mahruqi, A. S., Al Za'abi, M., Shalaby, A., Ashique, M., Nemmar, A., Ali, B. H.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-02-2017
• Subjects: adenine; Adenine - toxicity; Animals; blood flow; blood pressure; Blood Pressure - drug effects; chronic kidney disease; diesel exhaust particles; Immunohistochemistry; Kidney - blood supply; Kidney - drug effects; Kidney - pathology; Lung - pathology; Male; Particulate Matter - toxicity; Phenylephrine - pharmacology; Rats; Rats, Wistar; Renal Insufficiency, Chronic - chemically induced; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; Vehicle Emissions - toxicity; blood pressure; chronic kidney disease; diesel exhaust particles; blood flow; adenine
• ISSN: 1520-4081; 1522-7278
• DOI: 10.1002/tox.22258

ABSTRACT
Several recent studies have indicated the possible association between exposure to particulate air pollution and the increased rate of morbidity and mortality in patients with kidney diseases. The link of this observation to vascular damage has not been adequately addressed. Therefore, this study aims to investigate possible vascular damage that might be associated with exposure to diesel exhaust particles (DP) in adenine (AD)‐induced chronic kidney disease (CKD) in rats, and the possible ameliorative effect of gum acacia (GA). CKD was induced by feeding AD (0.75%, w/w), and DP (0.5 mg/kg) was instilled intratracheally every second day and GA was given concomitantly in the drinking water at a dose of 15% w/v. All treatments were given concomitantly for 28 days. Changes in renal blood flow (RBF) and systolic and diastolic blood pressure were monitored in these animals after anesthesia, together with several other endpoints. Exposure to DP significantly reduced RBF and this was significantly potentiated in AD‐treated rats. Phenylephrine‐induced decreases in RBF and increases in systolic and diastolic blood pressure were severely potentiated in rats exposed to DP, and these actions were significantly augmented in AD‐treated rats. GA did not significantly affect the vascular impairment induced by AD and DP given together. This study provides experimental evidence that exposure to particulate air pollution can exacerbate the vascular damage seen in patients with CKD. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 541–549, 2017.