Frailty as a predictor of outcomes in patients undergoing head and neck cancer surgery

• Published in: The Laryngoscope Vol. 130; no. 5; pp. E340 - E345
• Main Authors: Goldstein, David P., Sklar, Michael C., Almeida, John R., Gilbert, Ralph, Gullane, Patrick, Irish, Jonathan, Brown, Dale, Higgins, Kevin, Enepekides, Danny, Xu, Wei, Su, Jie, Alibhai, Shabbir M.H.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01-05-2020; Wiley Subscription Services, Inc
• Subjects: cancer; Cancer surgery; Elderly; Frailty; functional status; Head & neck cancer; head neck; frailty; cancer; functional status; head neck; Elderly
• ISSN: 0023-852X; 1531-4995
• DOI: 10.1002/lary.28222

Objectives
To evaluate whether frailty and functional measures are predictors of perioperative complications and length of hospital stay (LOS) in patients undergoing head and neck cancer surgery.
Study Design
Prospective study.
Methods
Patients 50 years and older undergoing major head and neck cancer surgery between 2011 and 2015 preoperatively completed Fried's Frailty Index, Barthel Index, Lawton‐Brody questionnaire and Vulnerable Elders Survey‐13. Primary outcome measures were postoperative complications and LOS, which were analyzed using multivariable logistic and linear regression models.
Results
There were 274 patients recruited (105 aged 50–64 and 169 aged 65 and older). Of these, 119, 132, and 23 were defined as non‐frail, pre‐frail, and frail, respectively. Frailty score and functional measures were not predictors of overall complications. In multivariable models, frailty score (odds ratio [OR] = 1.36; 95% confidence interval [CI], 1.04–1.78, P = .025) was a predictor of medical complications and Clavien‐Dindo Grade III and higher complications independent of age and comorbidity. Higher frailty score (β = 1.07; 95% CI, 1.02–1.12, P = .0025) and less independence on the Lawton Brody (β = −0.08; 95% CI, −0.11 to −0.05, P < .001) and Barthel Index (β = −0.12; 95% CI, −0.19 to −0.06, P < .001) were predictors of increased LOS.
Conclusions
Frailty was a predictor of type and severity of complications. Both frailty and measures of independence in activities of daily living were independent predictors of LOS. Frailty and functional assessment can help surgeons identify patients at risk of adverse postoperative outcomes and thus aid in counselling patients as well as identifying patients that may benefit from comprehensive geriatric assessment and targeted interventions.
Level of Evidence
Prognosis study 2b
Laryngoscope, 130:E340–E345, 2020