Dietary phytochemicals in cancer prevention and therapy: a complementary approach with promising perspectives

• Published in: Nutrition reviews Vol. 71; no. 9; pp. 585 - 599
• Main Authors: González‐Vallinas, Margarita, González‐Castejón, Marta, Rodríguez‐Casado, Arantxa, Ramírez de Molina, Ana
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley 01-09-2013; Oxford University Press
• Subjects: Anticarcinogenic Agents - therapeutic use; Biological and medical sciences; cancer; Cancer therapies; Diet; dietary phytochemicals; Dietary Supplements; Disease prevention; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Health education; Humans; Medical sciences; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasms - drug therapy; Neoplasms - prevention & control; Nutrigenomics; nutritional supplements; Phytochemicals; Plants - chemistry; polyphenols; Polyphenols - therapeutic use; prevention; Signal Transduction; therapy; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Micronutrient; Prevention; polyphenols; Polyphenol; dietary phytochemicals; nutritional supplements; Nutrition; therapy; nutrigenomics; Proanthocyanidin; Malignant tumor; Cancer; cancer; prevention
• ISSN: 0029-6643; 1753-4887
• DOI: 10.1111/nure.12051

The population is aging. Over the coming years, the incidence of age‐related chronic diseases such as cancer is expected to continue to increase. Phytochemicals, which are non‐nutritive chemicals found in plants and food, have emerged as modulators of key cellular signaling pathways exerting proven anticancer effects. The challenge now is to develop personalized supplements comprised of specific phytochemicals for each clinical situation. This will be possible once a better understanding is gained of the molecular basis explaining the impact of phytochemicals on human health. The aim of the present literature review is to summarize current knowledge of the dietary phytochemicals with proven antitumor activity, with a special emphasis placed on their molecular targets. Also discussed are the limits of existing research strategies and the future directions of this field.