Effects of intergeniculate leaflet lesions on circadian rhythms in the mouse

• Published in: Behavioural brain research Vol. 128; no. 1; pp. 13 - 17
• Main Authors: Lewandowski, Marian H, Usarek, Artur
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 07-01-2002; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Circadian clock; Circadian Rhythm - physiology; Darkness; Geniculate Bodies - physiology; Intergeniculate leaflet; Locomotor activity; Mice; Motor Activity - physiology; Mouse; Non-photic entrainment; Suprachiasmatic nucleus; Wheel-running activity; Circadian clock; Suprachiasmatic nucleus; Mouse; Non-photic entrainment; Intergeniculate leaflet; Locomotor activity; Wheel-running activity
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/S0166-4328(01)00264-9

We investigated effects of bilateral electrolytic intergeniculate leaflet (IGL) lesions (IGLX) on circadian rhythms of the wheel-running activity in mice kept under constant darkness conditions (DD). As a result of complete bilateral IGL lesions, the period of a free-running rhythm was lengthened by ca. 45 min in comparison with a pre-operational one. The present findings confirm results obtained previously with other animals. However, for the first time locomotor activity levels were precisely assessed in mice (the number of wheel revolutions/day) before and after IGL lesions. A computer analysis of data showed a considerable decrease in that activity (by 68% on an average) in mice with complete bilateral IGL lesions in comparison with IGL-non-lesioned individuals. The obtained results show that also in mice IGL constitutes an anatomically important element of the mechanism of a circadian time-keeping system, which mediates the transfer of non-photic information to the suprachiasmatic nuclei (SCN) by modulating their activity.