Single center observation of the role of pre-existing HLA-DP antibodies in humoral rejection following renal transplantation

HLA antigens, including HLA-A, B, C, DR and DQ have long been known to have an effect on transplant outcome. Presence of antibodies to these antigens is detrimental to transplant outcome as it ends up to either acute or chronic humoral rejection depending on the titer of the antibodies to these anti...

Full description

Saved in:

Bibliographic Details
Published in:	Transplant immunology Vol. 51; pp. 58 - 61
Main Authors:	Nikaein, A., Lerman, M., Rofaiel, G., Allam, S.R.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-12-2018
Subjects:	DSA CDC CPRA AMR LUR LD AHR HLA
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	HLA antigens, including HLA-A, B, C, DR and DQ have long been known to have an effect on transplant outcome. Presence of antibodies to these antigens is detrimental to transplant outcome as it ends up to either acute or chronic humoral rejection depending on the titer of the antibodies to these antigens. However, the role of HLA-DP is not fully clear, predominantly due to lack of adequate publications and the fact that DP antigen and antibody detection became possible with the advent of new beads technology. As a results, allocation system has not yet included HA-DP antibodies in virtual crossmatching. This report presents two novel cases with strong HLA-DP antibodies which resulted in acute humoral rejection (AMR).
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0966-3274 1878-5492
DOI:	10.1016/j.trim.2018.09.002