Olfactory gyrus intracerebral hemorrhage in a patient with COVID-19 infection

• Published in: Journal of clinical neuroscience Vol. 79; pp. 275 - 276
• Main Authors: Thu, Sai Si, Matin, Nassim, Levine, Steven R.
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01-09-2020
• Subjects: Betacoronavirus; Case Report; Cerebral Hemorrhage - diagnostic imaging; Cerebral Hemorrhage - etiology; Coronavirus Infections - complications; COVID-19; Humans; Intracerebral hemorrhage; Magnetic Resonance Imaging; Male; Middle Aged; Olfaction Disorders - etiology; Olfactory gyrus; Pandemics; Parietal Lobe - diagnostic imaging; Pneumonia, Viral - complications; SARS-CoV-2; SARS-CoV-2 infection; Smell; COVID-19; SARS-CoV-2 infection; Olfactory gyrus; Intracerebral hemorrhage
• ISSN: 0967-5868; 1532-2653
• DOI: 10.1016/j.jocn.2020.07.033

•Since the outbreak with novel corona virus in December 2019, a myriad of different neurological manifestations in patients with COVID-19 infection have been reported.•We present a case of non-traumatic intracranial hemorrhage in the olfactory gyrus in a patient who tested positive for SARS-COV-2.•The area of hemorrhage is not a common location for spontaneous hemorrhage.•Given that loss of smell is considered a relatively common symptom of this pandemic, it is an intriguing association of COVID-19 and olfactory gyrus ICH for neurotropism of SARS-CoV2 for olfactory bulb and glia cells through nasal mucosa.•Future studies will need to elucidate the exact mechanism of anosmia from COVID-19 and potential mechanisms leading to ICH.
Since the outbreak with novel corona virus in December 2019, a myriad of different neurological manifestations in patients with COVID-19 infection have been reported. We present a case of non-traumatic intracranial hemorrhage in the olfactory gyrus in a patient who tested positive for SARS-COV-2. The area of hemorrhage is not a common location for spontaneous hemorrhage. Given that loss of smell is considered a relatively common symptom of this pandemic, it is an intriguing association of COVID-19 and olfactory gyrus ICH for neurotropism of SARS-CoV2 for olfactory bulb and glia cells through nasal mucosa. Future studies will need to elucidate the exact mechanism of anosmia from COVID-19 and potential mechanisms leading to ICH.