A mild catalytic system for radical conjugate addition of nitrogen heterocycles

The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the...

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Bibliographic Details
Published in:	Chemical science (Cambridge) Vol. 8; no. 4; pp. 3121 - 3125
Main Authors:	Aycock, R A, Wang, H, Jui, N T
Format:	Journal Article
Language:	English
Published:	England 01-04-2017
Subjects:	Alkenes Conjugates Constraining Halides Nitrogen Pyridines Radicals Unions
Online Access:	Get full text
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Summary:	The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2041-6520 2041-6539
DOI:	10.1039/c7sc00243b