Speckle optical monitoring of blood microcirculation for different types of treatment of the vascular system

• Published in: Journal of applied spectroscopy Vol. 80; no. 2; pp. 299 - 304
• Main Authors: Khludeyev, I. I., Tserakh, A. S., Smirnov, A. V., Dick, S. K., Zorina, V. P.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-05-2013; Springer
• Subjects: Analytical Chemistry; Atomic/Molecular Structure and Spectra; Patient monitoring equipment; Physics; Physics and Astronomy; vascular system; speckle optical method; microcirculation; photodynamic treatment
• ISSN: 0021-9037; 1573-8647
• DOI: 10.1007/s10812-013-9762-z

We have studied correlations between the changes in the characteristics of the speckle field (spectral power, bandpass coefficient) and variations in blood microcirculation in different areas of the skin for different types of treatment. We have established that the properties of the photosensitizer have a considerable effect on the mechanism and dynamics of development of photosensitized damage to blood vessels. Comparison of photosensitized disturbances of the blood microcirculation when using chlorin e
6
and the dimethyl ester of chlorin e
6
showed that the dimethylester of chlorin e
6
is a more effective sensitizer for selective damage to the vascular system of the target tissue in photodynamic treatment. With the goal of developing a noninvasive speckle optical method for monitoring the status of the vascular system of the skin, we have designed a Speckle Scan device, the operation of which is based on analysis of the parameters of the dynamic speckle field created by reflection and scattering of the probing laser radiation by biological tissues.