Association of serum 25-hydroxy vitamin D status with cardiometabolic risk factors and total and regional obesity in southern Iran: evidence from the PoCOsteo study

• Published in: Scientific reports Vol. 14; no. 1; pp. 17983 - 11
• Main Authors: Nejabat, Alireza, Emamat, Hadi, Afrashteh, Sima, Jamshidi, Ali, Jamali, Zahra, Farhadi, Akram, Talkhabi, Zahra, Nabipour, Iraj, Larijani, Bagher, Spitz, Jörg
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03-08-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/163; 692/4019; 692/499; 692/53; Adipose tissue; Adiposity; Aged; Biochemical markers; Blood pressure; Body fat distribution; Body Mass Index; Cardiometabolic; Cardiometabolic Risk Factors; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cholesterol; Cross-Sectional Studies; Diabetes mellitus (non-insulin dependent); Dual energy X-ray absorptiometry; Dyslipidemia; Female; Health risks; Humanities and Social Sciences; Humans; Iran - epidemiology; Low density lipoprotein; Male; Middle Aged; multidisciplinary; Obesity; Obesity - blood; Obesity - epidemiology; Older people; Risk Factors; Science; Science (multidisciplinary); Triglycerides; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - epidemiology; Vitamin D3; Vitamin deficiency; Waist Circumference; Iran; Obesity; Body fat distribution; Cardiometabolic; Vitamin D
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-68773-1

Cardiometabolic risk factors increase the chance of developing cardiovascular disease (CVD) and type 2 diabetes. Most CVD risk factors are influenced by total and regional obesity. A higher risk of developing CVD may be linked to vitamin D deficiency, which is more prevalent in the older population. With the goal of evaluating the association between vitamin D and cardiometabolic risk factors and total and regional obesity in older adults, this research included 25 (OH) vitamin D3 concentrations and biochemical markers associated with cardiometabolic diseases, as well as total and regional adiposity, which was measured by DXA. A total of 1991 older participants in the PoCOsteo study were included. Overall, 38.5% of participants had vitamin D deficiency. After adjusting for confounders, the results of multiple linear and logistic regression suggested an inverse association between vitamin D and body mass index (P = 0.04), waist circumference (P = 0.001), total fat (P = 0.02), android fat (P = 0.001), visceral fat (P < 0.001), subcutaneous fat (P = 0.01), trunk fat (P = 0.006), arm fat (P = 0.03), high systolic blood pressure (P = 0.004), high total cholesterol (P < 0.001), high LDL-cholesterol (P < 0.001), high serum triglycerides (P = 0.001), and high fasting glucose (P < 0.001). Additionally, higher vitamin D concentrations decreased the risk of dyslipidemia by 2%. Our results showed a significant association between serum vitamin D and a number of cardiometabolic risk factors, including total and regional obesity.