Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells

Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After co...

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Bibliographic Details
Published in:	Nanoscale Vol. 7; no. 2; p. 415
Main Authors:	Slegerova, Jitka, Hajek, Miroslav, Rehor, Ivan, Sedlak, Frantisek, Stursa, Jan, Hruby, Martin, Cigler, Petr
Format:	Journal Article
Language:	English
Published:	England 14-01-2015
Subjects:	Acrylamides - chemistry Biocompatible Materials - chemistry Cell Line, Tumor Cell Survival - drug effects Click Chemistry Endocytosis Fluorescent Dyes - chemistry Glioma - metabolism Glioma - pathology Humans Integrin alphaVbeta3 - chemistry Integrin alphaVbeta3 - metabolism Microscopy, Confocal Nanodiamonds - chemistry Nanodiamonds - toxicity Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Silicon Dioxide - chemistry
Online Access:	Get more information
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Summary:	Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.
ISSN:	2040-3372
DOI:	10.1039/c4nr02776k